Food and Drink

Trial Updates: Novavax Approved, Potatoes Work

James Bailey1 Comment

I’m usually the one writing the papers, but I recently did two studies as a participant / guinea pig. Both just released major positive updates.

I joined the Novavax trial in late 2020 to have the chance to get a Covid vaccine sooner; at the time Pfizer had just got emergency approval but wasn’t available to the general public. The smart bio people on Twitter also seemed to think it was likely to be safer, and perhaps more effective, than other Covid vaccines (it delivers relevant proteins directly, rather than using mRNA or a viral vector). The trial results were published over a year ago now, and were in fact excellent:

Results from a Phase 3 clinical trial enrolling 29,960 adult volunteers in the United States and Mexico show that the investigational vaccine known as NVX-CoV2373 demonstrated 90.4% efficacy in preventing symptomatic COVID-19 disease. The candidate showed 100% protection against moderate and severe disease

As usual the FDA dragged its feet, even as other agencies around the world like the European Medical Agency and the World Health Organization approved the US-made Novavax. But last week it finally gave emergency authorization, and yesterday the CDC recommended Novavax. Of course, by now almost everyone who wants a Covid vaccine has one, and this approval is only for adults. But this will be a great option for boosters, as well as for anyone who was genuinely just concerned with the new technologies in the other vaccines (rather than just afraid of needles, or preferring to cut off their nose to spite authority’s face). As the CDC put it:

Protein subunit vaccines package harmless proteins of the COVID-19 virus alongside another ingredient called an adjuvant that helps the immune system respond to the virus in the future. Vaccines using protein subunits have been used for more than 30 years in the United States, beginning with the first licensed hepatitis B vaccine. Other protein subunit vaccines used in the United States today include those to protect against influenza and whooping cough….

Today, we have expanded the options available to adults in the U.S. by recommending another safe and effective COVID-19 vaccine. If you have been waiting for a COVID-19 vaccine built on a different technology than those previously available, now is the time to join the millions of Americans who have been vaccinated

I’m glad I was in this trial- I got a Covid vaccine several months before I otherwise could have, I made a few hundred dollars, and I learned a lot. But it would have been much better if they found a way to do fewer blood draws, and if FDA approval had come quicker. I’ve been in a weird gray area with respect to vaccine mandates for the last year; almost everyone ended up accepting my vaccine card, but I never knew if they were going to say “no, you need an FDA approved one”. I ended up getting Pfizer for a booster even though I think it’s a worse vaccine, partly for this reason, and partly because Novavax said they’d only give me the booster if I did another blood draw and I was tired of that.

The all-potato diet trial I wrote about here also released its results this week. This trial was much less formal, much smaller, and had no control group, so the results aren’t a slam-dunk the way Novavax is. But I think they’re still impressive. I lost 8 pounds in the 4-week trial, but it turns out the average participant who did all 4 weeks did even better:

Of the participants who made it four weeks, one lost 0 lbs…. Everyone else lost more than that. The mean amount lost was 10.6 lbs, and the median was 10.0 lbs.

Their summary also explains other costs and benefits of the diet, showing lots of data as well as many quotes from participants, including two from me. They conclude with some fascinating speculation about potential mechanisms from the boring (literally, lower variety makes eating boring so you eat less) to the speculative (low lithium? high potassium? weird lithium-potassium interactions), check it out if you’re interested in why obesity rates keep rising or if you’re considering doing the potato diet.

I’m glad I was in these two trials- what to try next?

Irish Superman: 4 Weeks of Potatoes

James Bailey1 Comment

Back in May I mentioned that a study was recruiting participants to try a 4-week all-potato diet. What I didn’t say was that I was joining the study, and I finished this week.

I’m glad I did it; I lost 8 pounds and 2 inches of waistline, going from slightly overweight (BMI 26) to just barely not-overweight (BMI 24.9). Here are some of my notes:

Day 5: Energy boost kicked in today. Feel half my age

Day 6: Potato energy going strong. Feel like Irish Superman

Day 15: Almost too much energy, hard to sit down at a computer and work, took a break to play basketball

So like many people who previously tried this, I can add more anecdotal evidence of weight loss (despite eating all the potatoes you want) and energy. I’ll also echo people who said that “hunger feels different” and not as demanding, and that it “resets your tastebuds” so that previously bland foods taste good (I just had a turnip with zero seasoning and it was almost too intense). Now to answer your likely questions:

Q: Did you actually eat nothing but potatoes for 4 weeks?

A: No, but I got reasonably close. I cooked potatoes in avocado oil and added seasonings, I drank coffee and beer, I ate other vegetables, I had some snacks. Overall I estimate I got 75-80% of my calories from potatoes.

Q: Was it hard to stick to? didn’t you get bored?

A: Being hungry or even bored weren’t really issues, all 5 times I slipped up and ate a meal that wasn’t potatoes I’d say it was for social reasons (I was at a party with great food, at a restaurant with someone, et c)

Q: What kinds of meals did you cook?

A: Lots of home fries and roast potatoes using lots of varieties of potato (russet, gold, red, purple, sweet). Mashed potatoes a few times. McCain’s craft beer fries for my birthday.

Q: Aren’t potatoes bad for you? Why didn’t this make you fat?

A: Anything can be bad for you if you deep-fry it, or otherwise smother it with fats or process it to death. This is probably how most potatoes get consumed in America, but they start as nutritious root vegetables.

Q: What about protein? Doesn’t this kill your gains?

A: This was my biggest concern going into the study. Potatoes do have more protein than I thought, enough to live on but probably not enough to make you strong. My lifts did come down a bit, though it’s unclear if that was due to the lack of protein or just the lower calories and weight loss taking some muscle along with the fat. I was eating high-protein yogurt many days to try to mitigate this.

Q: If this is so great, are you going to keep doing it?

A: No, it was great for the first 14-16 days then just ok. Most of the weight loss and energy boost happened in the first half. If I ever do this again I’m going to plan on two weeks, which I think is also what Penn Jillette suggests. I do think I’ll do potatoes for lunch a lot more often than I used to, and pivot this to a “whole foods / not-ultra-processed” diet.

Q: Is there something special about potatoes? Would any single-food diet work as well?

I’m not sure. Some of the benefit likely comes from cutting out variety, so not eating a lot just because “I need to try everything”. Some likely comes from cutting out specific categories of food, like high fat / high sugar / hyper-palatable. I don’t think that just any food would work, probably most whole foods would, but potatoes are cheap and nutritious. The potato diet leading to weight loss is consistent with many, though not all theories of obesity.

Q: Can I still sign up for the study?

A: No:

Signups are now closed, but we plan to do more potato diet studies in the future. If you’re interested in participating in a future potato diet study, you can give us your email at this link and we’ll let you know when we run the next study.

But you can always just do it yourself.

Eat 20 Potatoes a Day…. For Science

James Bailey3 Comments

Several people have tried eating an all-potato diet for a few weeks and reported losing lots of weight with little hunger or effort. Could this be the best diet out there? Or are we only hearing from the rare success stories, while all the people who tried it and failed stay quiet?

Right now we don’t really know, but the people behind the Slime Mold Time Mold blog are trying to find out:

Tl;dr, we’re looking for people to volunteer to eat nothing but potatoes (and a small amount of oil & seasoning) for at least four weeks, and to share their data so we can do an analysis. You can sign up below.

I was surprised to see that they are the ones running this, since they are best known for the “Chemical Hunger” series arguing that the obesity epidemic is largely driven by environmental contaminants like Lithium. The conclusion of that series noted:

Bestselling nutrition books usually have this part where they tell you what you should do differently to lose weight and stay lean. Many of you are probably looking forward to us making a recommendation like this. We hate to buck the trend, but we don’t think there’s much you can do to keep from becoming obese, and not much you can do to drop pounds if you’re already overweight. 

We gotta emphasize just how pervasive the obesity epidemic really is. Some people do lose lots of weight on occasion, it’s true, but in pretty much every group of people everywhere in the world, obesity rates just go up, up, up. We’ll return to our favorite quote from The Lancet: 

“Unlike other major causes of preventable death and disability, such as tobacco use, injuries, and infectious diseases, there are no exemplar populations in which the obesity epidemic has been reversed by public health measures.”

That said, they did still offer some advice based on the contaminant theory that is consistent with the potato diet:

1. — The first thing you should consider is eating more whole foods and/or avoiding highly processed foods. This is pretty standard health advice — we think it’s relevant because it seems pretty clear that food products tend to pick up more contaminants with every step of transportation, packaging, and processing, so eating local, unpackaged, and unprocessed foods should reduce your exposure to most contaminants. 

2. — The second thing you can do is try to eat fewer animal products. Vegetarians and vegans do seem to be slightly leaner than average, but the real reason we recommend this is that we expect many contaminants will bioaccumulate, and so it’s likely that whatever the contaminant, animal products will generally contain more than plants will. So this may not help, but it’s a good bet. 

Overall though I think the idea here is to ignore grand theories and take an empirical approach. The potato diet works surprisingly well anecdotally, so lets just see if it can work on a larger scale. Seems worth a try; I’m sure plenty of my ancestors in Ireland and Northern Maine did 4-week mostly-potato diets and lived to tell about it. You can read more and/or sign up here. Let us know how it goes if you actually try it!

Really Stable Prices

Jeremy HorpedahlLeave a comment

Breaking news in America this week: Little Caesars will be raising the price of their Hot-N-Ready Pizzas from $5 to $5.55. Some see this as a sign of the times, just another bit of bad news among all the inflation data lately. But what really surprised me is that this price has been stable they introduced it in 1997. This means that compared to median wages, these pizzas were about 50% cheaper than 1997 (before this price increase). That’s a doubling of America’s Pizza Standard of Living in just 24 years.

Keeping a fixed price is a somewhat rare, but fascinating pricing strategy. It can even become part of the identity of the product. The most famous example was Coca-Cola, which sold a 6.5 ounce bottle for 5 cents from 1886 to 1959. It’s so famous that it has its own Wikipedia page! “Always 5 cents” became a marketing slogan for them. And while we may regard that time period as one of generally low inflation, consumer prices on average more than tripled from 1886 to 1959.

Probably the most famous recent example is Costco’s $1.50 hot dog and soda combo, which has been stable in price since 1985. Rumor has it that the founder of Costco once told the current CEO that he’d kill him if he raised the price of the hot dog. Since 1985, nominal median wages in the US have tripled, meaning that your Costco Hot Dog Standard of Living has also tripled.

The concept of nickel and dime stores and later dollar stores are similar concepts, but they aren’t necessarily selling the exact same products over time. Coca-Cola, Hot-N-Ready pizzas, and Costco hot dogs really are the same product from year-to-year, so these products stand out as amazing examples of price stability during periods of time when most prices were rising in nominal terms (other than new technologies).

What are some other examples of consistently stable prices?

Pumpkin Spice: 15th Century Edition

Jeremy HorpedahlLeave a comment

It’s pumpkin spice season. That means that not only can you get pumpkin spice lattes, but also pumpkin spice Oreos, pumpkin spice Cheerios, and even pumpkin spice oil changes.

The most important thing to know about “pumpkin spice” things is that they don’t actually taste like pumpkin. They taste like the spices that you use to flavor pumpkin pie. (Notable exception: Peter Suderman’s excellent pumpkin spice cocktail syrup, which does contain pumpkin puree.)

Last week economic historian Anton Howes posted a picture of the spice shelf at his grocery store and guessed that this would have been worth millions of dollars in 1600.

Some of the comments pushed back a little. OK, probably not millions but certainly a lot. Howes was alluding to the well-known fact that spices used to be expensive. Very expensive. Spices, along with precious metals, were one of the primary reasons for the global exploration, trade, and colonialism for centuries. Finding and controlling spices was a huge source of wealth.

But how much more expensive were spices in the past? One comment on Howes’ tweet points to an excellent essay by the late economic historian John Munro on the history of spices. And importantly, Munro gives us a nice comparison of the prices of spices in 15th century Europe, including a comparison to typical wages.

As I looked at the list of spices in Munro’s essay, I noticed: these are the pumpkin spices! Cloves, cinnamon, ginger, and mace (from the nutmeg seed, though not exactly the same as nutmeg). He’s even included sugar. That’s all we need to make a pumpkin spice syrup!

Last week in my Thanksgiving prices post I cautioned against looking at any one price or set of prices in isolation. You can’t tell a lot about standards of living by looking at just a few prices, you need to look at all prices. So let me just reiterate here that the following comparison is not a broad claim about living standards, just a fun exercise.

That being said, let’s see how much the prices of spices have fallen.

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Happy 400th Thanksgiving from EWED

James BaileyLeave a comment

In 1621 the pilgrims were starving after their communal farming system gave them little incentive to work hard, leading them to rely on the generosity of their native neighbors at the first Thanksgiving. But in the long run they were able to produce their own feasts after switching to a private property system. Economist Ben Powell tells the story briefly here, or you can read the primary source, William Bradford’s Diary here.

It is customary in many families to “give thanks to the hands that prepared this feast” during the Thanksgiving dinner blessing. Perhaps we should also be thankful for the millions of other hands that helped get the dinner to the table: the grocer who sold us the turkey, the truck driver who delivered it to the store, and the farmer who raised it all contributed to our Thanksgiving dinner because our economic system rewards them

Powell calls this “the real lesson of Thanksgiving”, and while I think there are other great angles to the story this is certainly a real lesson of Thanksgiving.

Buying in Bulk: Money Saver or Self Sabotage?

Zachary Bartsch1 Comment

Recently, I’ve been buying a lot more non-durable goods when they are on sale. Whereas previously I might have purchased the normal amount plus one or two units, now I’m buying like 3x or 4x the normal amount.

What initially led me here was the nagging thought that a 50%-off sale is a superb investment – especially if I was going to purchase a bunch eventually anyway. I like to think that I’m relatively dispassionate about investing and finances. But I realized that I wasn’t thinking that way about my groceries. The implication is that I’ve been living sub-optimally. And I can’t have that!

If someone told me that I could pay 50% more on my mortgage this month and get a full credit on my mortgage payment next month, then I would jump at the opportunity. That would be a 100% monthly return. Why not with groceries? Obviously, some groceries go bad. Produce will wilt, dairy will spoil, and the fridge space is limited. But what about non-perishables? This includes pantry items, toiletries, cleaning supplies, etc. 

Typically, there are two challenges for investing in inventory: 1) Will the discount now be adequate to compensate for the opportunity cost of resources over time? 2)  Is there are opportunity cost to the storage space?

For the moment, I will ignore challenge 2). On the relevant margins, my shelf will be full or empty. I’ve got excess capacity in my house that I can’t easily adjust it nor lend out. That leaves challenge 1) only.

First, the Too Simple Version.

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Give the Gift of Cooking and Murder-Bears

James Bailey2 Comments

What is the point of reading non-fiction?

Hopefully it is entertaining, and you feel like you are learning something, though usually it is hard to recall much of a book a year after you read it. The best you can usually hope for is that it makes you look at the world differently. But how often does a book actually clearly change what you do?

While there are dozens, perhaps hundreds of books that changed how I think, Tim Ferriss’ books stand out for actually changing how I act. It was after reading The 4 Hour Body that I finally starting going to the gym every week, and it was after reading The 4 Hour Chef that I started to really cook.

Giving anything fitness-related as a gift can be dicey, so of the two I’d recommend The 4 Hour Chef as a gift. Its huge, its pretty, and its not just a book of recipes (though it has lots of them)- it is what made me think I no longer need recipes.

If instead you’d rather forget about big self-improvement books and just go for fun/entertaining, my best recommendation you’ve probably never heard of is Murder-Bears, Moonshine, and Mayhem: Strange Stories from the Bible to Leave You Amused, Bemused, and (Hopefully) Informed.

As a said as part of a review of my favorite non-fiction last year, its funny but not just funny. Its not just trying to highlight the craziest stories, its also full of lessons about how to read potentially confusing passages. “Murder-Bears” is a reference to the end of 2 Kings ch 2:

From there Elisha went up to Bethel. As he was walking along the road, some boys came out of the town and jeered at him. “Get out of here, baldy!” they said. “Get out of here, baldy!” He turned around, looked at them and called down a curse on them in the name of the Lord. Then two bears came out of the woods and mauled forty-two of the boys

Gifts for a Time of Inflation and Supply Bottlenecks

James Bailey1 Comment

I’ve never been great at gifts, and don’t have much in the way of specific ideas now. But I’ve been thinking about what the macroeconomic environment means for gift-giving.

First, as you’ve probably heard by now from us or elsewhere, if you want to get any physical gift I’d order it now, since shipping is a mess and prices are only going up. I’d especially recommend this for complex electronics that could become hard to find- its part of why I got my wife an iPad for her birthday this summer. Foreign food and drink that can be stockpiled is always a good idea, but perhaps especially now; think wine, Scotch, or Beirao liqueur (a Portuguese drink that was my favorite discovery this year). Wine and liquor make good stores of value in an time of inflation.

Alternatively, you could avoid the scarcity of physical goods by turning to the digital realm. If your economistic heart yearns to give cash, consider giving some your favorite stock or cryptocurrency instead- its both more personalized and less subject to inflation. Or if you think you can judge the recipient’s taste well enough, subscribe them to one of your favorite Substacks or podcasts. My recommendations:

Unsupervised Learning, Razib Khan– Genomics and History

The Diff, Byrne Hobart– Finance and Strategy

Astral Codex Ten, Scott Alexander– Rationality, Psychiatry, Everything

The Readers Karamazov– Funny podcast on literature and philosophy (now seems entirely free though)

Or if you really have money to burn, go for the Bloomberg subscription. I always run out of free reads on the Tyler Cowen articles and so can’t read Matt Levine, even though he has the magic ability to teach you finance while making you laugh. But the subscription is expensive and Mike Bloomberg doesn’t need the money, while the Substacks are relatively cheap and enable talented writers to spend a lot more time writing instead of needing to focus on a real job.

La Dolce Vita Economica

mdmakowskyLeave a comment

I thought about writing about soccer (again). I thought about writing about time management and personal production functions. I considered writing about Lebron James or how I manage multiple research projects. I thought about writing about a classic, and entirely addictive to the point of career ruination, video game. They all seem a little redundant at the moment, though, because they are all the same basic story.

One soccer manager is over-exhausting their resources because of a confluence of bad contractual incentives while another team is witnessing a renaissance in a player they essentially forced to take 7 weeks off. While so many NBA careers of the 80s evaporated in a cloud of cocaine and clubbing, Lebron James’ entire life is built around managing the only two resources whose limits are salient to his life: his body and relationship with his family. Playing baseball growing up I watched pitchers blow out their arms before they finished puberty in service to Little League glory, while modern professional pitchers are (finally) on strictly managed pitch counts to maximize their expected output.

There are two manners in which I armchair quarterback the rest of the world. One is the things in which I have just enough knowledge to be frustrated by others decisions, but no so much as to actually know what I am talking about. These frustrations are ephemeral, they flatter myself to the point of mild embarrassment upon reflection, and, if I am being honest with myself, are fun.

The other manner is resource management. These are the times when armchair quarterbacking is less fun and more exasperating because they are the moments when outsiders, with inferior levels of narrowly-applicable expertise, are often actually right. Which is not to say the knowledge that resources are being poorly managed is uniquely held by outsiders. Insiders are more often than not quite aware of the suboptimal deployment and conservation of resources, but are unable to overcome the status quo institutions, incentives, or inertia of decision-making power loci. It’s obvious to lots of people that athletes, CEOs, doctors, and congressional representatives are over-extended. What’s not obvious is how to get out of these equilibria.

When I see most attempts at self-improvement, I am generally skeptical of anything that doesn’t start with the identification of a key resource that is salient to outcomes and the options available to better manage it. Maybe its calories and how to budget them. Maybe its time and how to better partition and conserve it. It could always be money, but in general I find that money is so immediately identifiable as a finite resource and entirely fungible that people who ostensibly are managing it poorly are, in actuality, failing at managing a different resource (time, emotional energy, vices, etc) that is intertwined with financial resources.

When I see successful firms, teams, and individuals, what I most often find myself admiring is not (just) a worldly talent, but a facility with managing resources that others haven’t yet adopted or mimicked. An appreciation for sleep, a protection of time blocked for creativity, an adeptness trading low opportunity competitive minutes for higher opportunity cost moments on the biggest stages. Or even just the ability to recognize that this is the moment to savor a 600 calorie dessert with a loved one because the emotional sustenance will make it easier to walk away from three vending machine Hostess pies during the high-stress moments in the week to come.

Once you learn to manage your donut-based caloric intake, the spreadsheet of your life will be revealed before you, an endless cascade of resources to be managed and optimized. A life with the right donuts at the right time. The dolce vita economica.